Distinct childhood neurodevelopmental trajectories following very preterm birth

Introduction Very preterm birth (VPT; <32 weeks’ gestation) constitutes itself an environmental risk factor for a wide range of severe mental disorders. Particularly, 25% VPT screen positively autism spectrum disorder (ASD) and often present with co-occurring developmental difficulties, making it challenging to identify those likely develop ASD traits. Therefore, neurodevelopmental trajectories associated outcomes need be identified. Objectives Here, we investigated infant-to-childhood traits trajectories, their association comorbidities, in sample children screening negatively on the Modified Checklist Autism Toddlers (M-CHAT). Methods individuals from Evaluation Preterm Imaging study (ePrime) underwent behavioural assessments at 2 (M-CHAT Bayley Scales Infant Development; N=451) 4-7 years (Social Responsiveness Scale (SRS-2); N=251). To furtherly assess presence comorbid disorders aged years, further cognitive (WPPSI), ADHD (ADHD-RS-IV scale), emotional problems (SDQ ECBQ) were conducted. Results Findings ePRIME 4–7-year follow-up substudy will presented. grouped using M-CHAT scores, as they reportedly show distinct characteristics. Preliminary results showed that infancy are increased impairment. Conclusions infants may undescribed “at ASD” or cluster, clinical features differentiate them other “at-risk” populations. Our findings support routine preschool but also school ages; highlight importance interpreting screenings combination measures when assessing children. could guide clinicians researchers offer personalised interventions aimed supporting children’s development based phenotypic presentations. Further research is needed more accurate tools. Disclosure Interest None Declared